HRID2297059

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)Cc1c(C(=O)N[C@@H](CC(C)C)C(=O)NC(CC(=O)OC(C)(C)C)C(=O)COc2c(F)c(F)cc(F)c2F)n(C)c2ccccc12

HCID86756363

未命名化合物

PRODUCTS

生成物

结构：CC(C)Cc1c(C(=O)N[C@@H](CC(C)C)C(=O)NC(CC(=O)O)C(=O)COc2c(F)c(F)cc(F)c2F)n(C)c2ccccc12

HCID20639708

未命名化合物

收率 67%

PROCEDURE

实验过程

Treatment of N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenyloxy)-pentanoic acid, tert-butyl ester (47.6 mg, 0.070 mmol) with TFA as described in Example 80 gave the titled product (29.0 mg, 67%) as a white powder. MS C35H43F4N3O6, [M+Na]+=644, [M−H]−=620. TLC (CH2Cl2/MeOH, 90/10): Rf=0.19.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c8b9e24bd1f2453291b7b9c07b8c881b
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06489353B2
来源说明: uspto-grants-2002_12

反应 SMILES

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([CH3:14])[CH3:13])=[C:3]1[C:15]([NH:17][C@H:18]([C:23]([NH:25][CH:26]([C:35](=[O:48])[CH2:36][O:37][C:38]1[C:43]([F:44])=[C:42]([F:45])[CH:41]=[C:40]([F:46])[C:39]=1[F:47])[CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16].C(O)(C(F)(F)F)=O>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([CH3:14])[CH3:13])=[C:3]1[C:15]([NH:17][C@H:18]([C:23]([NH:25][CH:26]([C:35](=[O:48])[CH2:36][O:37][C:38]1[C:43]([F:44])=[C:42]([F:45])[CH:41]=[C:40]([F:46])[C:39]=1[F:47])[CH2:27][C:28]([OH:30])=[O:29])=[O:24])[CH2:19][CH:20]([CH3:21])[CH3:22])=[O:16]