Trifluoroacetic acid → HCID 18335068, compound

HRID 2297061Notes

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([CH3:14])[CH3:13])=[C:3]1[C:15]([N:17]([CH:46]1[CH2:51][CH2:50][CH2:49][CH2:48][CH2:47]1)[C@H:18]([C:20]([NH:22][CH:23]([C:32](=[O:45])[CH2:33][O:34][C:35](=[O:44])[C:36]1[C:41]([Cl:42])=[CH:40][CH:39]=[CH:38][C:37]=1[Cl:43])[CH2:24][C:25]([O:27]C(C)(C)C)=[O:26])=[O:21])[CH3:19])=[O:16].C(O)(C(F)(F)F)=O>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([CH3:14])[CH3:13])=[C:3]1[C:15]([N:17]([CH:46]1[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]1)[C@H:18]([C:20]([NH:22][CH:23]([C:32](=[O:45])[CH2:33][O:34][C:35](=[O:44])[C:36]1[C:37]([Cl:43])=[CH:38][CH:39]=[CH:40][C:41]=1[Cl:42])[CH2:24][C:25]([OH:27])=[O:26])=[O:21])[CH3:19])=[O:16]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86756367HCID 86756367, compound

Product 1

HCID 18335068HCID 18335068, compound

Procedure

Treatment of N-[(1-methyl-3-isobutyl-indole-2-cabonyl)cyclohexylalaninyl]-3-amino -5-(2,6-dichlorobenzoyl)oxy-4-oxo-pentanoic acid, tert-butyl ester with TFA as described in Example 80 gave the titled product (54.2 mg) as a white powder. MS C35H41Cl2N3O7, [M+H]+=686, [M−H]−=684. TLC (CH2Cl2/MeOH , 90/10): Rf=0.30.

Sources & evidence

ORD record: ord-ff1247e61b51491187df8c4e3858441e
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06489353B2

Reaction notes

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