2-Tert-Butylphenol → Cyclohexanol, 2-(1,1-dimethylethyl)-, (1R,2R)-rel-

HRID 2297078Notes

Reaction equation

HRID 2297078 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C(OC1CCCCC1C(C)(C)C)(=O)C.[H][H]>>[C:1]([C@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C@H:6]1[OH:11])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 69232-Tert-ButylphenolHCID 623342-tert-Butylcyclohexyl acetateHCID 178418361HCID 178418361, compound

Product 1

HCID 6995536Cyclohexanol, 2-(1,1-dimethylethyl)-, (1R,2R)-rel-

Procedure

A pressurized container fitted with stirrer is charged with 2-tertiary-butylphenol, 2-tertiary-butylcyclohexyl acetate and the catalyst. Hydrogenation is carried out at the chosen reaction temperature and hydrogen pressure. The resulting cis-2-tertiary-butylcyclohexanol is obtained following removal of the catalyst by filtration, decantation or centrifugation.

Workup

  1. customA pressurized container fitted with stirrer

Sources & evidence

ORD record
ord-5d06102f987e48c39d6f408953fbfe37
Source dataset
uspto-grants-2002_12
Patent number
US06489520B2

Reaction notes

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