HCID 22143020, compound → HCID 53977241, compound

HRID 2297150Notes

Reaction equation

HRID 2297150 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:24])[CH2:10][N:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1>CN(C(OC)OC)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:24])[C:10]([N:11]1[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])[CH2:15][CH2:16]1)=[CH:10][N:11]([CH3:16])[CH3:12]

Participants

3

Reactant 1

HCID 22143020HCID 22143020, compound

Product 1

HCID 53977241HCID 53977241, compound

Reagents, catalysts & solvents 1

HCID 78373Dimethylformamide dimethyl acetalSolvent

Procedure

1 mmol of tert-butyl 4-[2-(2,4-dichlorophenyl)-2-oxoethyl]piperazinecarboxylate was heated to 80 °C. in neat N,N-dimethylformamidedimethyl acetal for six hours. The reaction mixture was concentrated in vacuo and purified by trituration with diethyl ether to obtain tert-butyl 4-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxo-ethyl}piperazinecarboxylate.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by trituration with diethyl ether

Sources & evidence

ORD record
ord-e4cb6126c3024b21a4e23304a88482a3
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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