Phthalimide → HCID 86758632, compound

HRID 2297229Notes

Reaction equation

HRID 2297229 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=3[Cl:25])[C:15](NC(=O)CNC)=[CH:14][N:13]=2)[CH:5]=[CH:4][C:3]=1[N+:32]([O-:34])=[O:33].ClC1C=C(Cl)C=CC=1C(=O)CCl.C1(=O)[NH:51]C(=O)C2=CC=CC=C12.C(O[N:63]([CH2:67][C:68]([OH:70])=O)[C:64](C)=O)(C)(C)C>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=3[Cl:25])[C:15]([CH:67]([NH:63][CH3:64])[C:68]([NH2:51])=[O:70])=[CH:14][N:13]=2)[CH:5]=[CH:4][C:3]=1[N+:32]([O-:34])=[O:33]

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 202502,2',4'-TrichloroacetophenoneHCID 22142721HCID 22142721, compoundHCID 22143030HCID 22143030, compound

Product 1

HCID 86758632HCID 86758632, compound

Procedure

N-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-2-(methylamino)acetamide was made in accordance with the foregoing procedures through steps A using 1-(2,4-dichlorophenyl)-2-chloroethan-1-one and phthalimide, B, C using amino{2-[(6-amino-5-nitro(2-pyridyl))-amino]ethyl}carboxamidine, D, E, F using 2-[(tert-butoxy)-N-methylcarbonylamino]acetic acid, and G.

Sources & evidence

ORD record
ord-cb5b5dab7ea0445993a12df320e89ab7
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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