6-Chloro-3-nitropyridin-2-ylamine → HCID 178430858, compound

HRID 2297266Notes

Reaction equation

HRID 2297266 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[C:20]1[C:25]([C:26]2[NH:27][CH:28]=[C:29]([CH3:31])[N:30]=2)=[CH:24][N:23]=[C:22]([NH:32][CH2:33][CH2:34][NH:35]C2N=CC(C#N)=CC=2)[N:21]=1>>[NH2:1][C:2]1[N:3]=[C:4]([NH:35][CH2:34][CH2:33][NH:32][C:22]2[N:21]=[C:20]([C:14]3[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=3[Cl:12])[C:25]([C:26]3[NH:27][CH:28]=[C:29]([CH3:31])[N:30]=3)=[CH:24][N:23]=2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 27240356-Chloro-3-nitropyridin-2-ylamineHCID 178430853HCID 178430853, compound

Product 1

HCID 178430858HCID 178430858, compound

Procedure

{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2,4-dichlorophenyl)-5-(4-methylimidazol-2-yl)pyrimidin-2-yl]amine was prepared from 2-amino-6-chloro-3-nitropyridine using the general method for 6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methylimidazol-2-yl)-pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile.

Sources & evidence

ORD record
ord-e62a0008887745c68d99c2c6b8ab1f48
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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