HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid tert-butyl ester → (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid tert-butyl ester | HCID 53649195 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid | HCID 54198668 | 99.3% |
Reaction Steps
A solution of (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid tert-butyl ester (113 mg, 0.2 mmol) in TFA (2 ml) was stirred at room temperature for 30 min. After completion of the reaction, TFA was removed by evaporation in vacuo. Purification of the residue by silica gel column chromatography (using dichloromethane:methanol=9:1 as an eluent) gave (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid (101 mg, 99% yield) as a colorless amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489440B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c8c3450320594387af8708a5296c18b6 |
| Source note | uspto-grants-2002_12 |