HRID2297319

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCCCCNC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21

HCID53649195

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCNC(=O)[C@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21

HCID54198668

未命名化合物

收率 99.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID6422

未命名化合物

2 次

PROCEDURE

实验过程

A solution of (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid tert-butyl ester (113 mg, 0.2 mmol) in TFA (2 ml) was stirred at room temperature for 30 min. After completion of the reaction, TFA was removed by evaporation in vacuo. Purification of the residue by silica gel column chromatography (using dichloromethane:methanol=9:1 as an eluent) gave (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-undecylsuccinamic acid (101 mg, 99% yield) as a colorless amorphous solid.

WORKUP

后处理

customwas removed by evaporation in vacuo
customPurification of the residue by silica gel column chromatography (

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c8c3450320594387af8708a5296c18b6
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06489440B1
来源说明: uspto-grants-2002_12

反应 SMILES

C([O:5][C:6](=[O:41])[CH2:7][C@H:8]([NH:23][C:24]([O:26][CH2:27][CH:28]1[C:40]2[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=2[C:34]2[C:29]1=[CH:30][CH:31]=[CH:32][CH:33]=2)=[O:25])[C:9]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:10])(C)(C)C>C(O)(C(F)(F)F)=O.CO>[CH:30]1[C:29]2[CH:28]([CH2:27][O:26][C:24]([NH:23][C@H:8]([C:9]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:10])[CH2:7][C:6]([OH:41])=[O:5])=[O:25])[C:40]3[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=3)[C:34]=2[CH:33]=[CH:32][CH:31]=1