6,7-Difluoro-2-(6-hexyloxypyridin-3-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthalene → 6,7-Difluoro-5-(2-fluorodecyloxy)-2-(6-hexyloxypyridin-3-yl)-1,2,3,4-tetrahydronaphthalene

HRID 2297343Notes

Reaction equation

HRID 2297343 reaction equation
[F:1][C:2]1[C:3]([OH:26])=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[CH2:8][CH:7]([C:13]1[CH:14]=[N:15][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:17][CH:18]=1)[CH2:6][CH2:5]2.[F:27][C@@H:28]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH2:29]O>>[F:1][C:2]1[C:3]([O:26][CH2:29][CH:28]([F:27])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[CH2:8][CH:7]([C:13]1[CH:14]=[N:15][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:17][CH:18]=1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 183810986,7-Difluoro-2-(6-hexyloxypyridin-3-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthaleneHCID 22857780HCID 22857780, compound

Product 1

HCID 183811316,7-Difluoro-5-(2-fluorodecyloxy)-2-(6-hexyloxypyridin-3-yl)-1,2,3,4-tetrahydronaphthalene

Procedure

From 6,7-difluoro-2-(6-hexyloxypyridin-3-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthalene and 2-(S)-fluorodecan-1-ol by means of the Mitsunobu reaction.

Sources & evidence

ORD record
ord-f170ca07dd8d4a4aa981233729bcab00
Source dataset
uspto-grants-2002_12
Patent number
US06491989B1

Reaction notes

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