Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2297343Generated: October 30, 2026

6,7-Difluoro-2-(6-hexyloxypyridin-3-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthalene → 6,7-Difluoro-5-(2-fluorodecyloxy)-2-(6-hexyloxypyridin-3-yl)-1,2,3,4-tetrahydronaphthalene

https://huagongshe.com/reaction/2297343

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7-Difluoro-2-(6-hexyloxypyridin-3-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthaleneHCID 18381098—
ReactantHCID 22857780HCID 22857780—
Product6,7-Difluoro-5-(2-fluorodecyloxy)-2-(6-hexyloxypyridin-3-yl)-1,2,3,4-tetrahydronaphthaleneHCID 18381131—

Reaction Steps

From 6,7-difluoro-2-(6-hexyloxypyridin-3-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthalene and 2-(S)-fluorodecan-1-ol by means of the Mitsunobu reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06491989B1
Source datasetuspto-grants-2002_12
ORD IDord-f170ca07dd8d4a4aa981233729bcab00
Source noteuspto-grants-2002_12