2,3-Epoxyhexanol → 5-Hexyloxy-2-[1,6,7-trifluoro-5-(3-propyloxiranylmethoxy)naphthalen-2-yl]-pyrimidine
Reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:14]3[N:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:16][N:15]=3)[C:8]=2[F:13])[C:3]=1[OH:27].[CH2:28]([CH:31]1[O:33][CH:32]1[CH2:34]O)[CH2:29][CH3:30]>>[CH2:21]([O:20][C:17]1[CH:18]=[N:19][C:14]([C:7]2[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][C:11]([F:12])=[C:2]([F:1])[C:3]=3[O:27][CH2:34][CH:32]3[CH:31]([CH2:28][CH2:29][CH3:30])[O:33]3)[C:8]=2[F:13])=[N:15][CH:16]=1)[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]Participants
3
Procedure
From 2,3,5-trifluoro-6-(5-hexyloxypyrimidin-2-yl)naphthalen-1-ol and (3-propyloxiranyl)methanol by means of the Mitsunobu reaction.
Sources & evidence
- ORD record
- ord-c9b5c5fa426b45c9962e15c4facf74ea
- Source dataset
- uspto-grants-2002_12
- Patent number
- US06491989B1
Reaction notes
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