2,3-Epoxyhexanol → 2-[6,7-Difluoro-5-(3-propyloxiranylmethoxy)naphthalen-2-yl]-5-hexyloxypyrimidine

HRID 2297355Notes

Reaction equation

HRID 2297355 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:13]3[N:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:15][N:14]=3)[CH:8]=2)[C:3]=1[OH:26].[CH2:27]([CH:30]1[O:32][CH:31]1[CH2:33]O)[CH2:28][CH3:29]>>[F:1][C:2]1[C:3]([O:26][CH2:33][CH:31]2[CH:30]([CH2:27][CH2:28][CH3:29])[O:32]2)=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[CH:8]=[C:7]([C:13]1[N:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:17][N:18]=1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 5435652,3-EpoxyhexanolHCID 154053192,3-Difluoro-6-(5-hexyloxypyrimidin-2-yl)naphthalen-1-ol

Product 1

HCID 154053202-[6,7-Difluoro-5-(3-propyloxiranylmethoxy)naphthalen-2-yl]-5-hexyloxypyrimidine

Procedure

From 2,3-difluoro-6-(5-hexyloxypyrimidin-2-yl)naphthalen-1-ol and (3-propyloxiranyl)methanol by means of the Mitsunobu reaction.

Sources & evidence

ORD record
ord-1e6aaef641f14c1ca74ffadd2fd59d32
Source dataset
uspto-grants-2002_12
Patent number
US06491989B1

Reaction notes

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