HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Diazinan-2-imine hydrochloride → Tert-butyl (2s)-2-benzyloxycarbonylamino-3-(4-((1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)methyloxy)benzoylamino)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Diazinan-2-imine hydrochloride | HCID 22557527 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Tert-butyl (2s)-2-(benzyloxycarbonylamino)-3-(4-(methoxycarbonylmethyloxy)benzoylamino)propionate | HCID 56996374 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Tert-butyl (2s)-2-benzyloxycarbonylamino-3-(4-((1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)methyloxy)benzoylamino)propionate | HCID 57208730 | — |
Reaction Steps
438 mg of tert-butyl (2S)-2-(benzyloxycarbonylamino)-3-(4-(methoxycarbonylmethyloxy)benzoylamino)propionate, 606 mg of potassium tert-butoxide and 732 mg of 2-amino-1,4,5,6-tetrahydropyrimidine hydrochloride were dissolved in 10 ml of absolute dimethylformamide, and the solution was stirred at room temperature for 14 h and then concentrated to dryness in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492356B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-4d830e6a73ff4f618f44c74ddf97ed51 |
| Source note | uspto-grants-2002_12 |