HRID2297389

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22557527

1,4,5,6-Tetrahydropyrimidin-2-amine--hydrogen chloride (1/1)

C4H10ClN3

HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

结构：COC(=O)COc1ccc(C(=O)NC[C@H](NC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)cc1

HCID56996374

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(OCC(=O)NC2=NCCCN2)cc1)NC(=O)OCc1ccccc1

HCID57208730

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

438 mg of tert-butyl (2S)-2-(benzyloxycarbonylamino)-3-(4-(methoxycarbonylmethyloxy)benzoylamino)propionate, 606 mg of potassium tert-butoxide and 732 mg of 2-amino-1,4,5,6-tetrahydropyrimidine hydrochloride were dissolved in 10 ml of absolute dimethylformamide, and the solution was stirred at room temperature for 14 h and then concentrated to dryness in vacuo.

WORKUP

后处理

concentrationconcentrated to dryness in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4d830e6a73ff4f618f44c74ddf97ed51
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06492356B1
来源说明: uspto-grants-2002_12

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:20][NH:21][C:22](=[O:35])[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31](OC)=[O:32])=[CH:25][CH:24]=1)[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C)([O-])C.[K+].Cl.[NH2:43][C:44]1[NH:45][CH2:46][CH2:47][CH2:48][N:49]=1>CN(C)C=O>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:20][NH:21][C:22](=[O:35])[C:23]1[CH:24]=[CH:25][C:26]([O:29][CH2:30][C:31](=[O:32])[NH:43][C:44]2[NH:49][CH2:48][CH2:47][CH2:46][N:45]=2)=[CH:27][CH:28]=1)[C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1