Hydrochloric Acid → HCID 135767938, compound

HRID 2297451Notes

Reaction equation

HRID 2297451 reaction equation
C([O:8][C:9]1[C:18]([O:19][CH3:20])=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[N:12][N:13]=[C:14]2[CH2:21][C:22]1[C:27]([Cl:28])=[CH:26][N:25]=[CH:24][C:23]=1[Cl:29])C1C=CC=CC=1.[ClH:30]>C(O)(=O)C.C1(C)C=CC=CC=1>[ClH:28].[ClH:30].[Cl:29][C:23]1[CH:24]=[N:25][CH:26]=[C:27]([Cl:28])[C:22]=1[CH2:21][C:14]1[C:15]2[CH:16]=[CH:17][C:18]([O:19][CH3:20])=[C:9]([OH:8])[C:10]=2[CH:11]=[N:12][N:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18381678HCID 18381678, compound

Product 1

HCID 135767938HCID 135767938, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 1140TolueneSolvent

Procedure

5-Benzyloxy-1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazine (4.3 g, 10.08 mmoles), prepared as described in example 71, in glacial acetic acid and 7% HCl was put in a flask under stirring at room temperature for ½ hour, then at 60° C. for 1 hour. The mixture was brought to dryness, taken up more times in toluene to give a solid which was triturated in acetone and dried to give 4.04 g of the title compound (yield: 98%).

Workup

  1. waitat 60° C. for 1 hour
  2. customto give a solid which
  3. customwas triturated in acetone
  4. customdried

Sources & evidence

ORD record
ord-ddd348b777fb40df82aaabe21e946b7d
Source dataset
uspto-grants-2002_12
Patent number
US06492360B1

Reaction notes

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