Dichloromethane → HCID 9903689, compound

HRID 2297487Notes

Reaction equation

HRID 2297487 reaction equation
[CH2:1]([O:3][C:4]([CH:6]=[CH:7][O-])=[O:5])[CH3:2].[K+].[Br-].[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[CH:18]([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[O:17][C:16]2=O.C(Cl)Cl.O.[NH2:46][NH2:47]>C(O)C>[CH2:1]([O:3][C:4](=[O:5])[CH2:6][CH2:7][C:18]1[C:19]2[C:15](=[CH:14][C:13]([O:12][CH3:11])=[CH:21][CH:20]=2)[C:16](=[O:17])[NH:47][N:46]=1)[CH3:2]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 24654Hydrazine hydrate (1:1)HCID 11562468(5-Methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)triphenyl phosphonium bromideHCID 74088755HCID 74088755, compound

Product 1

HCID 9903689HCID 9903689, compoundYield 37.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Operating analogously to what described in example 113 starting from potassium 2-ethoxycarbonyl-ethenolate (771 mg, 5 mmoles), (5-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-triphenyl-phosphonium bromide (2.53 g, 5 mmoles), prepared as described in example 36, CH2Cl2 (20 ml) and hydrazine monohydrate (250 mg, 5 mmoles) in ethanol (20 ml), 0.52 g of the title compound were obtained.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-681786b7a42a451e91ce3a637e4eef85
Source dataset
uspto-grants-2002_12
Patent number
US06492360B1

Reaction notes

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