HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 3-(4-Chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 9903689 | HCID 9903689 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-Chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl ester | HCID 86757648 | 84.8% |
Reaction Steps
Operating analogously to example 114 starting from 3-(6-methoxy-4-oxo-3,4-dihydrophthalazin-1-yl)-propionic acid ethyl ester (552 mg, 2 mmoles), prepared as described in example 119, and POCl3 (1.12 ml, 12 mmoles) in acetonitrile (5 ml), 0.5 g of the title compound were obtained (yield: 84.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492360B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-7917ac6332e04b6593bb82461c1bc122 |
| Source note | uspto-grants-2002_12 |