Phosphorus oxychloride → 3-(4-Chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl ester

HRID 2297489Notes

Reaction equation

HRID 2297489 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][CH2:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10](=O)[NH:9][N:8]=1)[CH3:2].O=P(Cl)(Cl)[Cl:23]>C(#N)C>[CH2:1]([O:3][C:4](=[O:20])[CH2:5][CH2:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([Cl:23])=[N:9][N:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 9903689HCID 9903689, compound

Product 1

HCID 867576483-(4-Chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl esterYield 84.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Operating analogously to example 114 starting from 3-(6-methoxy-4-oxo-3,4-dihydrophthalazin-1-yl)-propionic acid ethyl ester (552 mg, 2 mmoles), prepared as described in example 119, and POCl3 (1.12 ml, 12 mmoles) in acetonitrile (5 ml), 0.5 g of the title compound were obtained (yield: 84.8%).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-7917ac6332e04b6593bb82461c1bc122
Source dataset
uspto-grants-2002_12
Patent number
US06492360B1

Reaction notes

Loading…