Sodium Hydroxide → 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid

HRID 2297491Notes

Reaction equation

HRID 2297491 reaction equation
C([O:3][C:4](=[O:24])[CH2:5][CH2:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)=[N:9][N:8]=1)C.[OH-].[Na+]>CO>[CH3:18][O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[C:7]([CH2:6][CH2:5][C:4]([OH:24])=[O:3])=[N:8][N:9]=[C:10]2[C:19]1[S:20][CH:21]=[CH:22][N:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 540412213-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester

Product 1

HCID 183816323-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acidYield 82.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Operating analogously to what described in example 118 starting from 3-(6-methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester (1.05 g, 3.06 mmoles), prepared as described in example 122, CH3OH (25 ml) and 10% NaOH (2.5 ml, 6.25 mmoles), 0.8 g of the title compound were obtained (yield: 82.9%). m.p.: 228-229° C.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-b4be20f35f994a34b81edd8f18fc5d95
Source dataset
uspto-grants-2002_12
Patent number
US06492360B1

Reaction notes

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