HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester | HCID 54041221 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid | HCID 18381632 | 82.9% |
Reaction Steps
Operating analogously to what described in example 118 starting from 3-(6-methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester (1.05 g, 3.06 mmoles), prepared as described in example 122, CH3OH (25 ml) and 10% NaOH (2.5 ml, 6.25 mmoles), 0.8 g of the title compound were obtained (yield: 82.9%). m.p.: 228-229° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492360B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-b4be20f35f994a34b81edd8f18fc5d95 |
| Source note | uspto-grants-2002_12 |