Tetrahydrofuran → HCID 86758636, compound

Participants

Reaction Steps

Isatoic anhydride (6.0 g) and 3-aminopropanol (2.8 ml) were dissolved in tetrahydrofuran (100 ml) and the mixture was stirred at room temperature for 4 hours. Tetrahydrofuran was removed and the residue was purified by silica gel chromatography (ethyl acetate) to obtain 5.94 g of N-(3-hydroxypropyl)(2-aminophenyl)formamide. Yield: 83%.

Provenance & Evidence