Tetrahydrofuran → HCID 86758636, compound

HRID 2297511Notes

Reaction equation

HRID 2297511 reaction equation
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6][C:5](=[O:12])OC2=O.[NH2:13]CCCO.[O:18]1C[CH2:21][CH2:20][CH2:19]1>>[OH:18][CH2:19][CH2:20][CH2:21][N:6]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[NH2:13])[CH:5]=[O:12]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8359Isatoic AnhydrideHCID 90863-Amino-1-propanol

Product 1

HCID 86758636HCID 86758636, compoundYield 83%

Procedure

Isatoic anhydride (6.0 g) and 3-aminopropanol (2.8 ml) were dissolved in tetrahydrofuran (100 ml) and the mixture was stirred at room temperature for 4 hours. Tetrahydrofuran was removed and the residue was purified by silica gel chromatography (ethyl acetate) to obtain 5.94 g of N-(3-hydroxypropyl)(2-aminophenyl)formamide. Yield: 83%.

Workup

  1. customTetrahydrofuran was removed
  2. customthe residue was purified by silica gel chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-e8866223d40941e2a26c9097fe9fc5f7
Source dataset
uspto-grants-2002_12
Patent number
US06492364B1

Reaction notes

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