Potassium Carbonate → 3-(Diphenylmethyl)piperidine

Participants

Reaction Conditions

Reaction Steps

1-acetyl-3-(diphenylmethyl)piperidine (250 mg) was added to methanol (12 ml) and 10N aqueous potassium hydroxide solution (4 ml), and the mixture was stirred at 80° C. for 3 hours. Aqueous saturated potassium carbonate solution was added to the reaction solution and the mixture was extracted once with ethyl acetate, followed by drying the organic layer over anhydrous sodium sulfate. The solvent was removed to obtain 220 mg of 3-(diphenylmethyl)piperidine. Yield: 100%.

Provenance & Evidence