Potassium Carbonate → 3-(Diphenylmethyl)piperidine

HRID 2297518Notes

Reaction equation

HRID 2297518 reaction equation
C([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5]1)(=O)C.[OH-].[K+].C(=O)([O-])[O-].[K+].[K+]>CO>[C:11]1([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]2[CH2:7][CH2:8][CH2:9][NH:4][CH2:5]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14797Potassium HydroxideHCID 18381944HCID 18381944, compound

Product 1

HCID 183819333-(Diphenylmethyl)piperidineYield 102.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

1-acetyl-3-(diphenylmethyl)piperidine (250 mg) was added to methanol (12 ml) and 10N aqueous potassium hydroxide solution (4 ml), and the mixture was stirred at 80° C. for 3 hours. Aqueous saturated potassium carbonate solution was added to the reaction solution and the mixture was extracted once with ethyl acetate, followed by drying the organic layer over anhydrous sodium sulfate. The solvent was removed to obtain 220 mg of 3-(diphenylmethyl)piperidine. Yield: 100%.

Workup

  1. extractionthe mixture was extracted once with ethyl acetate
  2. dry with materialby drying the organic layer over anhydrous sodium sulfate
  3. customThe solvent was removed

Sources & evidence

ORD record
ord-6df8d981c4d04faea1b1b24a21ed1018
Source dataset
uspto-grants-2002_12
Patent number
US06492364B1

Reaction notes

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