HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glutaric anhydride → 4-(N-(2-formylphenyl)carbamoyl)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glutaric anhydride | HCID 7940 | — |
| Reactant | 2-Aminobenzaldehyde | HCID 68255 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-(N-(2-formylphenyl)carbamoyl)butanoic acid | HCID 18381954 | 93% |
Reaction Steps
2-aminobenzaldehyde (2.87 g) and glutaric anhydride (3.26 g) were dissolved in benzene (60 ml) and the mixture was heated to reflux for 10.5 hours. Benzene was removed and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:1- ethyl acetate) to obtain 5.12 g of 4-(N-(2-formylphenyl)carbamoyl)butanoic acid. Yield: 93%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492364B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-1a75c3bfb9164c90aef14835fb5ab249 |
| Source note | uspto-grants-2002_12 |