反应详情

2-aminobenzaldehyde (2.87 g) and glutaric anhydride (3.26 g) were dissolved in benzene (60 ml) and the mixture was heated to reflux for 10.5 hours. Benzene was removed and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:1- ethyl acetate) to obtain 5.12 g of 4-(N-(2-formylphenyl)carbamoyl)butanoic acid. Yield: 93%.

1. temperaturethe mixture was heated
2. temperatureto reflux for 10.5 hours
3. customBenzene was removed
4. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:1- ethyl acetate)