反应详情

Dimethyl 2-ketoglutarate (3.75 g) and o-phenylenediamine (2.5 g) were dissolved in methanol (30 ml), and the mixture was stirred overnight. The precipitated crystals were recovered by filtration and washed with water and methanol to obtain 5.06 g of methyl 3-(3-hydroxyquinoxaline-2-yl)propanoate Yield: 94%.

1. filtrationThe precipitated crystals were recovered by filtration
2. washwashed with water and methanol