O-Phenylenediamine → HCID 178500070, compound

HRID 2297522Notes

Reaction equation

HRID 2297522 reaction equation
O=[C:2]([CH2:7][CH2:8][C:9]([O:11]C)=O)[C:3]([O:5][CH3:6])=[O:4].[C:13]1([NH2:20])[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH2:19]>CO>[OH:11][C:9]1[C:8]([CH2:7][CH2:2][C:3]([O:5][CH3:6])=[O:4])=[N:19][C:14]2[C:13]([N:20]=1)=[CH:18][CH:17]=[CH:16][CH:15]=2

Participants

4

Reactant 2

HCID 7243O-PhenylenediamineHCID 25775Dimethyl alpha-ketoglutarate

Product 1

HCID 178500070HCID 178500070, compoundYield 101.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dimethyl 2-ketoglutarate (3.75 g) and o-phenylenediamine (2.5 g) were dissolved in methanol (30 ml), and the mixture was stirred overnight. The precipitated crystals were recovered by filtration and washed with water and methanol to obtain 5.06 g of methyl 3-(3-hydroxyquinoxaline-2-yl)propanoate Yield: 94%.

Workup

  1. filtrationThe precipitated crystals were recovered by filtration
  2. washwashed with water and methanol

Sources & evidence

ORD record
ord-1ecbb4076d184381b57f51e787aa11c2
Source dataset
uspto-grants-2002_12
Patent number
US06492364B1

Reaction notes

Loading…