Acetic Acid → Acetate

HRID 2297542Notes

Reaction equation

HRID 2297542 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]4[N:33]=C(C)O[N:30]=4)=[CH:25][CH:24]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[C:35]([OH:38])(=[O:37])[CH3:36]>CO.[Ni]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:16][CH2:17][N:18]([C:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([NH2:33])=[NH:30])=[CH:25][CH:24]=3)=[O:22])[CH2:19][CH2:20]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2.[C:35]([O-:38])(=[O:37])[CH3:36]

Participants

6

Reactant 2

HCID 176Acetic AcidHCID 15860382HCID 15860382, compound

Product 2

HCID 175AcetateHCID 9955728HCID 9955728, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 100 mg of [4-(6-chloronaphthalene-2-sulphonyl)piperazin-1-yl][4-(5-methyl[1,2,4]oxadiazol-3-yl)phenyl]methanone in 5 ml of methanol is admixed with 100 mg of Raney nickel and a drop of acetic acid and hydrogenated to completion at atmospheric pressure and room temperature. Catalyst and solvent are removed, giving 4-[4-(6-chloronaphthalene-2-sulphonyl)piperazin-1-carbonyl]benzamidine, acetate, FAB 457.

Workup

  1. customat atmospheric pressure and room temperature
  2. customCatalyst and solvent are removed

Sources & evidence

ORD record
ord-a947f771d7d0475aa505412b3c834fe3
Source dataset
uspto-grants-2002_12
Patent number
US06492368B1

Reaction notes

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