HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 15860382 | HCID 15860382 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Acetate | HCID 175 | — |
| Product | HCID 9955728 | HCID 9955728 | — |
Reaction Steps
A solution of 100 mg of [4-(6-chloronaphthalene-2-sulphonyl)piperazin-1-yl][4-(5-methyl[1,2,4]oxadiazol-3-yl)phenyl]methanone in 5 ml of methanol is admixed with 100 mg of Raney nickel and a drop of acetic acid and hydrogenated to completion at atmospheric pressure and room temperature. Catalyst and solvent are removed, giving 4-[4-(6-chloronaphthalene-2-sulphonyl)piperazin-1-carbonyl]benzamidine, acetate, FAB 457.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492368B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-a947f771d7d0475aa505412b3c834fe3 |
| Source note | uspto-grants-2002_12 |