4-N-Propylbenzenesulphonyl chloride → HCID 18382269, compound

HRID 2297545Notes

Reaction equation

HRID 2297545 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][C:14]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[O:15])=[CH:9][CH:8]=2)[N:3]=1.[CH2:22]([C:25]1[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27][CH:26]=1)[CH2:23][CH3:24]>>[CH2:22]([C:25]1[CH:30]=[CH:29][C:28]([S:31]([N:19]2[CH2:20][CH2:21][N:16]([C:14](=[O:15])[CH2:13][C:10]3[CH:11]=[CH:12][C:7]([C:4]4[N:3]=[C:2]([CH3:1])[O:6][N:5]=4)=[CH:8][CH:9]=3)[CH2:17][CH2:18]2)(=[O:33])=[O:32])=[CH:27][CH:26]=1)[CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 27372224-N-Propylbenzenesulphonyl chlorideHCID 18382310HCID 18382310, compound

Product 1

HCID 18382269HCID 18382269, compound

Procedure

Similarly to Example 1, reaction of 2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-1-piperazin-1-ylethan-1-one (“B”) and 4-propylphenylsulphonyl chloride gives the compound 1-[4-(4-propylphenylsulphonyl)piperazin-1-yl]-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]ethan-1-one and, after hydrogenation, 4-{2-oxo-2-[4-(4-propylphenylsulphonyl)piperazin-1-yl]ethyl}benzamidine, FAB 429.

Sources & evidence

ORD record
ord-25859e14ed544ccfa99481821bd8cb0f
Source dataset
uspto-grants-2002_12
Patent number
US06492368B1

Reaction notes

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