Methyl chloroformate → methyl N-[4-[4-(6-chloronaphthalen-2-yl)sulfonylpiperazine-1-carbonyl]benzenecarboximidoyl]carbamate

HRID 2297549Notes

Reaction equation

HRID 2297549 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[NH:28])=[CH:25][C:24]=3C)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl[C:34]([O:36][CH3:37])=[O:35]>ClCCl>[CH3:37][O:36][C:34](=[O:35])[NH:29][C:27](=[NH:28])[C:26]1[CH:25]=[CH:24][C:23]([C:21]([N:18]2[CH2:17][CH2:16][N:15]([S:12]([C:7]3[CH:6]=[CH:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=4)[CH:8]=3)(=[O:13])=[O:14])[CH2:20][CH2:19]2)=[O:22])=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 183822934-[4-(6-Chloro-2-naphthylsulphonyl)piperazine-1-carbonyl]-3-methylbenzamidine

Product 1

HCID 145840733methyl N-[4-[4-(6-chloronaphthalen-2-yl)sulfonylpiperazine-1-carbonyl]benzenecarboximidoyl]carbamate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By reaction of 4-[4-(6-chloro-2-naphthylsulphonyl)piperazine-1-carbonyl]-3-methylbenzamidine with methyl chloroformate in dichloromethane, the compound methyl(imino-{4-[4- (6-chloro-2-naphthylsulphonyl)piperazine-1-carbonyl]phenyl}methyl)carbamate is obtained after customary work-up

Sources & evidence

ORD record
ord-6d0f007a0da6494e98a9989bf4a06818
Source dataset
uspto-grants-2002_12
Patent number
US06492368B1

Reaction notes

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