Methyl iodide → HCID 18382648, compound

HRID 2297613Notes

Reaction equation

HRID 2297613 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][C:9]([CH3:15])([CH3:14])[N:10]=[CH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[I:16][CH3:17]>CC(C)=O>[I-:16].[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][C:9]([CH3:15])([CH3:14])[N+:10]([CH3:17])=[CH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18382576HCID 18382576, compound

Product 1

HCID 18382648HCID 18382648, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
25 °C

Procedure

7-Nitro-3,3-dimethyl-3,4-dihydroisoquinoline (1.0 g, 4.9 mmol) in acetone (100 ml) was treated with iodomethane (1 ml, 16 mmol). The mixture was stirred at 25° C. for 18 h and the resultant precipitate collected by filtration and dried; pale yellow powder (1.5 g, 88%).

Workup

  1. filtrationthe resultant precipitate collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-ad5a959a6a9b49f094c171b59f0befc5
Source dataset
uspto-grants-2002_12
Patent number
US06492378B1

Reaction notes

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