Potassium Carbonate → HCID 18382715, compound

HRID 2297626Notes

Reaction equation

HRID 2297626 reaction equation
[CH3:1][C:2]1([CH3:33])[CH2:11][C:10]2[C:5](=[CH:6][C:7]([NH:12][C:13](=[O:26])[C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=3)=[CH:8][CH:9]=2)[CH2:4][N:3]1C(=O)C(F)(F)F.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:1][C:2]1([CH3:33])[CH2:11][C:10]2[C:5](=[CH:6][C:7]([NH:12][C:13](=[O:26])[C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([C:22]([F:24])([F:23])[F:25])[CH:15]=3)=[CH:8][CH:9]=2)[CH2:4][NH:3]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 9956539HCID 9956539, compound

Product 1

HCID 18382715HCID 18382715, compoundYield 86.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a stirred solution of N-(3,3-dimethyl-1,2,3,4-tetrahydro-2-trifluoroacetylisoquinolin-7-yl)-4-methoxy-3-trifluoromethyl benzamide (442 mg; 0.93 mmol) in methanol (50 ml) and water (25 ml) was added potassium carbonate (642 mg; 4.65 mmol) and the resultant mixture heated under reflux for I h. Evaporation in vacuo gave a residue which was partitioned between dichloromethane and water. The organic phase was dried over sodium sulfate, and evaporation in vacuo gave the title compound (303 mg).

Workup

  1. temperatureunder reflux for I
  2. customEvaporation in vacuo
  3. customgave a residue which
  4. customwas partitioned between dichloromethane and water
  5. dry with materialThe organic phase was dried over sodium sulfate, and evaporation in vacuo

Sources & evidence

ORD record
ord-4efffe3b3e3a44f09d9e4933c6787859
Source dataset
uspto-grants-2002_12
Patent number
US06492378B1

Reaction notes

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