Hydrazine hydrate (1:1) → HCID 69828295, compound

HRID 2297653Notes

Reaction equation

HRID 2297653 reaction equation
CO[C:3]([C@@H:5]1[C@@H:12]2[C@@H:8]([O:9][C:10]([CH3:14])([CH3:13])[O:11]2)[C@H:7]([N:15]2[CH:23]=[N:22][C:21]3[C:16]2=[N:17][CH:18]=[N:19][C:20]=3[NH:24][CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)[O:6]1)=[O:4].O.[NH2:31][NH2:32]>CO>[CH:25]1([NH:24][C:20]2[N:19]=[CH:18][N:17]=[C:16]3[C:21]=2[N:22]=[CH:23][N:15]3[C@H:7]2[C@@H:8]3[O:9][C:10]([CH3:14])([CH3:13])[O:11][C@@H:12]3[C@@H:5]([C:3]([NH:31][NH2:32])=[O:4])[O:6]2)[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 69827870HCID 69827870, compound

Product 1

HCID 69828295HCID 69828295, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3aS,4S,6R,6aR)-6-(6-cyclopentylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid methyl ester (0.48 g) and hydrazine hydrate (0.29 ml) in methanol (10 ml) was heated at reflux for 28 h. After cooling to room temperature, the mixture was concentrated in vacuo and the residue evaporated twice with dichloromethane (2×20 ml) to give the title compound as a white solid (0.49 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 28 h
  3. concentrationthe mixture was concentrated in vacuo
  4. customthe residue evaporated twice with dichloromethane (2×20 ml)

Sources & evidence

ORD record
ord-45a5d8e1f66d46c583be3ca6ef5698ff
Source dataset
uspto-grants-2002_12
Patent number
US06492348B1

Reaction notes

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