Hydrazine hydrate (1:1) → HCID 69827444, compound

HRID 2297657Notes

Reaction equation

HRID 2297657 reaction equation
CO[C:3]([C@@H:5]1[C@@H:12]2[C@@H:8]([O:9][C:10]([CH3:14])([CH3:13])[O:11]2)[C@H:7]([N:15]2[CH:23]=[N:22][C:21]3[C:16]2=[N:17][CH:18]=[N:19][C:20]=3[NH:24][CH:25]([CH3:27])[CH3:26])[O:6]1)=[O:4].O.[NH2:29][NH2:30]>CO>[CH:25]([NH:24][C:20]1[N:19]=[CH:18][N:17]=[C:16]2[C:21]=1[N:22]=[CH:23][N:15]2[C@H:7]1[C@@H:8]2[O:9][C:10]([CH3:14])([CH3:13])[O:11][C@@H:12]2[C@@H:5]([C:3]([NH:29][NH2:30])=[O:4])[O:6]1)([CH3:26])[CH3:27]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 69827563HCID 69827563, compound

Product 1

HCID 69827444HCID 69827444, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3aS,4S,6R,6aR)-6-(6-isopropylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid methyl ester (3.76 g) and hydrazine hydrate (1.26 ml) in methanol (140 ml) was heated under reflux for 48 h. After cooling to room temperature, the mixture was concentrated in vacuo and the residue triturated with ethyl acetate to afford the title compound as a white solid (3.3 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 48 h
  3. concentrationthe mixture was concentrated in vacuo
  4. customthe residue triturated with ethyl acetate

Sources & evidence

ORD record
ord-0e15c86f48214c47b677c5131e0cc384
Source dataset
uspto-grants-2002_12
Patent number
US06492348B1

Reaction notes

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