Potassium Carbonate → HCID 9883844, compound

HRID 2297698Notes

Reaction equation

HRID 2297698 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[S:16][C:17]([Cl:20])=[CH:18][CH:19]=2)=[O:14])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6](C(=O)C(F)(F)F)[CH2:7]2.C(=O)([O-])[O-].[K+].[K+]>CO>[Cl:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[S:16][C:17]([Cl:20])=[CH:18][CH:19]=2)=[O:14])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 11774554HCID 11774554, compound

Product 1

HCID 9883844HCID 9883844, compoundYield 59.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the compound of Procedure 2 (148 mg, 0.35 mmol) and potassium carbonate (800 mg, 5.8 mmol) in 20% aqueous methanol (50 ml) was stirred at 25° C. for 18 h. Work-up similar to Description 3 gave the title compound as a white solid (68 mg).

Sources & evidence

ORD record
ord-503e2d810f784b9ab614daed874dfb5b
Source dataset
uspto-grants-2002_12
Patent number
US06492388B1

Reaction notes

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