Hydrochloric Acid → HCID 18382885, compound

HRID 2297779Notes

Reaction equation

HRID 2297779 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1.[NH:9]1[C:17]2[C:12](=[CH:13][C:14]([NH:18][C:19]3[C:20]4[S:27][C:26]([C:28]5[CH:35]=[CH:34][C:31]([CH:32]=O)=[CH:30][CH:29]=5)=[CH:25][C:21]=4[N:22]=[CH:23][N:24]=3)=[CH:15][CH:16]=2)[CH:11]=[CH:10]1.Cl>>[N:6]1[CH:7]=[N:8][CH:4]([CH2:3][CH2:2][NH:1][CH2:32][C:31]2[CH:30]=[CH:29][C:28]([C:26]3[S:27][C:20]4[C:19]([NH:18][C:14]5[CH:13]=[C:12]6[C:17](=[CH:16][CH:15]=5)[NH:9][CH:10]=[CH:11]6)=[N:24][CH:23]=[N:22][C:21]=4[CH:25]=3)=[CH:35][CH:34]=2)[CH:5]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehydeHCID 178419017HCID 178419017, compound

Product 1

HCID 18382885HCID 18382885, compound

Procedure

The title compound was prepared from histamine and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. The product was converted to the mesylate salt analogous to example 17 being converted to the HCl salt. 1H NMR (400 MHz, DMSO) d 11.1 (s, 1H), 9.61 (s, 1H), 8.47 (s, 1H), 7.83 (m, 3H), 7.66 (s, 1H), 7.57 (m, 2H), 7.38 (m, 2H), 7.24 (m, 1H), 6.95 (s, 1H), 6.42 (s, 1H), 4.22 (s, 2H), 3.15 (m, 2H)2.82 (m, 2H); LC-MS: 466 (MH+); HPLC RT: 3.76 minutes.

Sources & evidence

ORD record
ord-74abbc50f4b14a129aae8a9a8ebfa9a7
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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