Hydrochloric Acid → (1H-Indol-5-yl)-[6-(4-{[(thiophen-2-ylmethyl)-amino]-methyl}-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-amine

HRID 2297780Notes

Reaction equation

HRID 2297780 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH2:7].[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[C:19]4[S:26][C:25]([C:27]5[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=5)=[CH:24][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1.Cl>>[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[C:19]4[S:26][C:25]([C:27]5[CH:34]=[CH:33][C:30]([CH2:31][NH:7][CH2:6][C:2]6[S:1][CH:5]=[CH:4][CH:3]=6)=[CH:29][CH:28]=5)=[CH:24][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 34005(2-Thienylmethyl)amineHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

Product 1

HCID 18383061(1H-Indol-5-yl)-[6-(4-{[(thiophen-2-ylmethyl)-amino]-methyl}-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-amine

Procedure

The title compound was prepared from C-thiophen-2-yl-methylamine and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. The product was converted to the mesylate salt analogous to example 17 being converted to the HCl salt. M. P.111-121° C.; LC-MS: 468 (MH+); HPLC RT: 4.44 minutes.

Sources & evidence

ORD record
ord-03933b7e2014461895697cc6f9b99f3c
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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