Furfurylamine → [6-(4-{[(Furan-2-ylmethyl)-amino]-methyl}-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-(1H-indol-5-yl)-amine

HRID 2297781Notes

Reaction equation

HRID 2297781 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH2:7].[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[C:19]4[S:26][C:25]([C:27]5[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=5)=[CH:24][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:31][C:30]1[CH:29]=[CH:28][C:27]([C:25]2[S:26][C:19]3[C:18]([NH:17][C:13]4[CH:12]=[C:11]5[C:16](=[CH:15][CH:14]=4)[NH:8][CH:9]=[CH:10]5)=[N:23][CH:22]=[N:21][C:20]=3[CH:24]=2)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 3438FurfurylamineHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

Product 1

HCID 18383049[6-(4-{[(Furan-2-ylmethyl)-amino]-methyl}-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-(1H-indol-5-yl)-amine

Procedure

The title compound was prepared from C-furan-2-yl-methylamine and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. M.P. 125-134° C.; LC-MS: 452 (MH+); HPLC RT: 4.51 minutes.

Sources & evidence

ORD record
ord-c66911ad8d09449a9d28cfe0ef01a875
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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