4-(Methylthio)phenylboronic acid → (1H-Indol-5-yl)-[2-(4-methylsulfanyl-phenyl)-thieno[3,2-b]pyridin-7-yl]-amine

HRID 2297799Notes

Reaction equation

HRID 2297799 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:13]1[S:21][C:20]2[C:15](=[N:16][CH:17]=[CH:18][C:19]=2[NH:22][C:23]2[CH:24]=[C:25]3[C:29](=[CH:30][CH:31]=2)[NH:28][CH:27]=[CH:26]3)[CH:14]=1>>[NH:28]1[C:29]2[C:25](=[CH:24][C:23]([NH:22][C:19]3[CH:18]=[CH:17][N:16]=[C:15]4[CH:14]=[C:13]([C:6]5[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=5)[S:21][C:20]=34)=[CH:31][CH:30]=2)[CH:26]=[CH:27]1

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 18382766(2-bromo-thieno[3,2-b]pyridin-7-yl)-(1H-indol-5-yl)-amine

Product 1

HCID 9865061(1H-Indol-5-yl)-[2-(4-methylsulfanyl-phenyl)-thieno[3,2-b]pyridin-7-yl]-amine

Procedure

The title compound was prepared from 4-(methylthio)benzeneboronic acid and (2-bromo-thieno[3,2-b]pyridin-7-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 17. 1H NMR (400 MHz, DMSO) d 11.4 (s, 1H), 10.6 (s, 1H), 8.30 (d, 1H), 7.53 (m, 9H), 7.05 (d, 1H), 6.43 (s, 1H), 2.48 (s, 3H); LC-MS: 388 (MH+); HPLC RT: 6.07 minutes.

Sources & evidence

ORD record
ord-688f0a89971b4783af75e444c95b8283
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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