6-(Diethylamino)-2-benzofurancarboxaldehyde → 1-(5-carboxy-pentyl)-4-[(E)-2-(6-diethylamino-benzofuran-2-yl)-vinyl]-6-sulfonato-chinolinium betaine

HRID 229780Notes

Reaction equation

HRID 229780 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[C:4]1[CH:14]=[CH:13][C:7]2[CH:8]=[C:9]([CH:11]=O)[O:10][C:6]=2[CH:5]=1)[CH3:2].[C:17]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][N+:25]1[C:34]2[C:29](=[CH:30][C:31]([S:35]([O-:38])(=[O:37])=[O:36])=[CH:32][CH:33]=2)[C:28]([CH3:39])=[CH:27][CH:26]=1)([OH:19])=[O:18].[CH3:40][N+:41]([CH2:44][C:45]([OH:47])=[O:46])([CH3:43])[CH3:42]>CO.O>[C:17]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][N+:25]1[C:34]2[C:29](=[CH:30][C:31]([S:35]([O-:38])(=[O:37])=[O:36])=[CH:32][CH:33]=2)[C:28](/[CH:39]=[CH:11]/[C:9]2[O:10][C:6]3[CH:5]=[C:4]([N:3]([CH2:1][CH3:2])[CH2:15][CH3:16])[CH:14]=[CH:13][C:7]=3[CH:8]=2)=[CH:27][CH:26]=1)([OH:19])=[O:18].[CH3:40][N+:41]([CH2:44][C:45]([OH:47])=[O:46])([CH3:43])[CH3:42]

Participants

4

Reactant 2

HCID 147167106-(Diethylamino)-2-benzofurancarboxaldehydeHCID 1317275391-(5-Carboxy-pentyl)-4-methyl-6-sulfonato-chinolinium betaine

Product 1

HCID 1317275401-(5-carboxy-pentyl)-4-[(E)-2-(6-diethylamino-benzofuran-2-yl)-vinyl]-6-sulfonato-chinolinium betaine

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

0.2 mmol 6-diethylamino-benzofuran-2-carbaldehyde and 0.2 mmol 1-(5-carboxy-pentyl)-4-methyl-6-sulfonato-chinolinium betaine are converted according to the general directions given above. Column chromatography: SiO2 (RP18), eluent: methanol/water.

Sources & evidence

ORD record
ord-b547ae899ff64f9997e290c94269ff67
Source dataset
uspto-grants-2009_07
Patent number
US07563907B2

Reaction notes

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