HCID 2757862, compound → HCID 18382814, compound

HRID 2297810Notes

Reaction equation

HRID 2297810 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:6]=[CH:7][CH:8]=1.Cl[C:18]1[C:19]2[S:26][C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:24][C:20]=2[N:21]=[CH:22][N:23]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:18]3[C:19]4[S:26][C:25]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)=[CH:24][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:14][CH:15]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 2757862HCID 2757862, compoundHCID 476408976754-70-6

Product 1

HCID 18382814HCID 18382814, compoundYield 17%

Procedure

Utilizing a procedure analogous to that described in Example 61, the title compound was prepared in 17% yield from added N-(3-methoxy-phenyl)-benzene-1,4-diamine (100 mg, 0.405 mmol) and 4-chloro-6-phenyl-thieno[3,2-d]pyrimidine (100 mg, 0.405 mmol). RP18-HPLC RT: 6.833 minutes; API MS: 425.53 (M+1); MP: 189-191° C.

Sources & evidence

ORD record
ord-ebf8b0c44d7148519f5ca3337e74cd4f
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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