(5-Methylthiophen-2-yl)boronic acid → HCID 18382838, compound

HRID 2297842Notes

Reaction equation

HRID 2297842 reaction equation
[CH3:1][C:2]1[S:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:11]1[S:19][C:18]2[C:13](=[N:14][CH:15]=[CH:16][C:17]=2[NH:20][C:21]2[CH:22]=[C:23]3[C:27](=[CH:28][CH:29]=2)[NH:26][C:25]([CH3:30])=[CH:24]3)[CH:12]=1>>[CH3:30][C:25]1[NH:26][C:27]2[C:23]([CH:24]=1)=[CH:22][C:21]([NH:20][C:17]1[CH:16]=[CH:15][N:14]=[C:13]3[CH:12]=[C:11]([C:5]4[S:6][C:2]([CH3:1])=[CH:3][CH:4]=4)[S:19][C:18]=13)=[CH:29][CH:28]=2

Participants

3

Reactant 2

HCID 2734374(5-Methylthiophen-2-yl)boronic acidHCID 183828502-Bromo-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

Product 1

HCID 18382838HCID 18382838, compound

Procedure

The title compound was prepared from 5-methylthiophene-2-boronic acid and (2-bromothieno[3,2-b]pyridin-7-yl)-(2-methyl-1H-indol-5-yl)-amine by the procedure analogous to example 2 above. 1H NMR (400 MHz, CD3OD) δ8.03 (d, 1H), 7.29 (m, 3H), 7.15 (s, 1H), 6.99 (m, 1H), 6.83 (d, 1H), 6.54 (d, 1H), 6.10 (s, 1H), 2.41 (s, 3H), 2.22 (s, 3H); RP18-HPLC RT: 6.08 minutes; API MS: 376 (M+1).

Sources & evidence

ORD record
ord-ab012cf6015443e0a13db80f210c3ed7
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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