5-Amino-2-methylindole → HCID 18383063, compound

HRID 2297847Notes

Reaction equation

HRID 2297847 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[C:23]([CH3:35])=[N:24][C:25]([N:28]4[C:32]([CH3:33])=[CH:31][CH:30]=[C:29]4[CH3:34])=[CH:26][CH:27]=3)[S:21][C:14]=12>>[CH3:33][C:32]1[N:28]([C:25]2[N:24]=[C:23]([CH3:35])[C:22]([C:20]3[S:21][C:14]4[C:15](=[N:16][CH:17]=[CH:18][C:13]=4[NH:11][C:7]4[CH:8]=[C:9]5[C:4](=[CH:5][CH:6]=4)[NH:3][C:2]([CH3:1])=[CH:10]5)[CH:19]=3)=[CH:27][CH:26]=2)[C:29]([CH3:34])=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382752HCID 18382752, compound

Product 1

HCID 18383063HCID 18383063, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 7-chloro-2-[6-(2,5-dimethyl-pyrrol-1-yl)-2-methyl-pyridin-3-yl]-thieno[3,2-b]pyridine by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.08 (s, 1H), 7.82 (d, 1H), 7.40 (s, 1H), 7.30 (s, 1H), 7.25 (d, 1H), 7.07 (d, 1H), 6.92 (dd, 1H), 6.58 (d, 1H), 6.07 (s, 1H), 5.80 (s, 2H), 2.60 (s, 3H), 2.36 (s, 3H), 2.05 (s, 6H); RP18-HPLC RT: 6.55 minutes; API MS: 464 (M+1).

Sources & evidence

ORD record
ord-2dfe9f6558824c1fbf9ff40e03c09636
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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