5-Amino-2-methylindole → HCID 69995829, compound

HRID 2297852Notes

Reaction equation

HRID 2297852 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[S:19][C:18]3[C:13](=[N:14][CH:15]=[CH:16][C:17]=3Cl)[CH:12]=2)[N:6]=1)=[O:4].[CH3:21][C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([NH2:31])=[CH:26][CH:25]=2>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[S:19][C:18]3[C:13](=[N:14][CH:15]=[CH:16][C:17]=3[NH:31][C:27]3[CH:28]=[C:29]4[C:24](=[CH:25][CH:26]=3)[NH:23][C:22]([CH3:21])=[CH:30]4)[CH:12]=2)[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 69994396HCID 69994396, compound

Product 1

HCID 69995829HCID 69995829, compound

Procedure

The title compound was prepared from 6-(7-chloro-thieno[3,2-b]pyridin-2-yl)-pyridine-2-carboxylic acid methyl ester and 2-methyl-5-aminoindole by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.43 (d, 1H), 8.22 (s, 1H), 8.18 (d, 1H), 8.11 (t, 1H), 8.02 (d, 1H), 7.26 (m, 2H), 6.92 (d, 1H), 6.59 (d, 1H), 6.10 (s, 1H), 3.89 (s, 3H), 2.36 (s, 3H); RP18-HPLC RT: 5.34 minutes; API MS: 415 (M+1).

Sources & evidence

ORD record
ord-7e92ea0da8ea426fa859029dc7ba9ea0
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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