反应详情

Sodium azide (0.56 g, 8.62 mmol) was added to a solution of racemic (1S,4R,7R)-4-methyl-8-oxa-3-aza-bicyclo[5.1.0]octane-3-carboxylic acid benzyl ester (0.75 g, 2.87 mmol) and ammonium chloride (0.46 g, 8.62 mmol) in MeOH (5 ml) and H2O (0.5 ml), then was refluxed for 6 h. The reaction mixture was concentrated in vacuo by rotary evaporation, then was diluted with water (5 ml) and extracted with EtOAc (10 ml). The organic layer was then extracted with water, brine, dried with MgSO4, filtered, concentrated in vacuo by rotary evaporation, and chromatographed (silica gel, 20% EtOAc/hexanes) to yield the title compound (0.7 g, 80%): 7.39-7.30 (m, 5H), 5.15 (2H, s), 4.10-3.67 (m, 2H), 3.10 (1H, d), 1.85-1.53 (m, 4H), 1.09 (3H, d); Liquid Chromatgraphy/Electrospray mass spec: M+H+=305.2.

1. temperaturewas refluxed for 6 h
2. concentrationThe reaction mixture was concentrated in vacuo by rotary evaporation
3. additionwas diluted with water (5 ml)
4. extractionextracted with EtOAc (10 ml)
5. extractionThe organic layer was then extracted with water, brine
6. dry with materialdried with MgSO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo by rotary evaporation
9. customchromatographed (silica gel, 20% EtOAc/hexanes)