反应详情

The product of Example 4b (1 g) and 5% Pd/C (300 mg) suspended in cumene (50 mL) and NMP (5 mL) was heated at reflux for 16 h. The mixture was then filtered and concentrated. The residue was diluted with methanol (10 mL) and added to water, after 1 h the resulting precipitate was collected by filtration and dried to yield the title compound (0.9 g).

1. temperatureat reflux for 16 h
2. filtrationThe mixture was then filtered
3. concentrationconcentrated
4. additionThe residue was diluted with methanol (10 mL)
5. additionadded to water, after 1 h the resulting precipitate
6. filtrationwas collected by filtration
7. customdried