Hydrochloric Acid → HCID 178479505, compound

Participants

Reaction Steps

A suspension of [1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrate (1.28 g, 3.59 mmol) in tetrahydrofuran (38.4 mL) with vigorous stirring was treated with concentrated hydrochloric acid (0.30 mL, 3.6 mmol). The mixture became homogeneous within one minute and then a solid began to precipitate. The resulting mixture was stirred vigorously for 1 h and filtered. The solid was air-dried to provide 1.11 g (82% yield) of the title compound.

Provenance & Evidence