Hydrochloric Acid → HCID 178479505, compound

HRID 2298028Notes

Reaction equation

HRID 2298028 reaction equation
O.O.[N:3]1[C:12]2[C:7](=[C:8]([N:13]3[C:17]([CH:18]4[CH2:20][CH2:19]4)=[C:16]([C:21]([NH:23][C:24]([NH2:26])=[NH:25])=[O:22])[CH:15]=[N:14]3)[CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[ClH:27]>O1CCCC1>[OH2:22].[ClH:27].[N:3]1[C:12]2[C:7](=[C:8]([N:13]3[C:17]([CH:18]4[CH2:20][CH2:19]4)=[C:16]([C:21]([NH:23][C:24]([NH2:26])=[NH:25])=[O:22])[CH:15]=[N:14]3)[CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178513082HCID 178513082, compound

Product 1

HCID 178479505HCID 178479505, compoundYield 165%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of [1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrate (1.28 g, 3.59 mmol) in tetrahydrofuran (38.4 mL) with vigorous stirring was treated with concentrated hydrochloric acid (0.30 mL, 3.6 mmol). The mixture became homogeneous within one minute and then a solid began to precipitate. The resulting mixture was stirred vigorously for 1 h and filtered. The solid was air-dried to provide 1.11 g (82% yield) of the title compound.

Workup

  1. customto precipitate
  2. stirringThe resulting mixture was stirred vigorously for 1 h
  3. filtrationfiltered
  4. customThe solid was air-dried

Sources & evidence

ORD record
ord-8711b76ecdd549bebba39b14a57e32ef
Source dataset
uspto-grants-2002_12
Patent number
US06492401B1

Reaction notes

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