HCID 11133523, compound → HCID 11058459, compound

HRID 2298031Notes

Reaction equation

HRID 2298031 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=O)[CH2:12][NH:13][C:14](=[O:30])[NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:17]=2)=[CH:3]1>C(O)(=O)C>[CH2:28]([O:27][C:25]([N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:16]([N:15]2[C:11]([C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:2]([CH3:1])[CH:3]=3)=[CH:12][NH:13][C:14]2=[O:30])=[CH:17]1)=[O:26])[CH3:29]

Participants

3

Reactant 1

HCID 11133523HCID 11133523, compound

Product 1

HCID 11058459HCID 11058459, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
110 °C

Procedure

The product of step b) (2.63 g, 6.29 mmol) was suspended in acetic acid (30.0 ml) and heated to 110° C. until all the starting material has been consumed after about 3 hours. The solvent was removed and the residue titurated with diethyl ether to give the sub-title compound (1.84 g, 74%) as an off-white solid.

Workup

  1. customhas been consumed after about 3 hours
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-cab3fe286bd94e82ab62acb6db397b0b
Source dataset
uspto-grants-2002_12
Patent number
US06492409B1

Reaction notes

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